AlphaMissense

DeepMind releases AlphaGenome Atlas mapping 9 billion variants

Google DeepMind introduced AlphaGenome Atlas, which provides precomputed predictions of the molecular effects of roughly 9 billion single-nucleotide variants across the human genome, available for academic research via a free website. DeepMind also released the AVI (AlphaGenome Variant Impact) score that combines AlphaGenome and AlphaMissense predictions for rapid ranking and interpretation of variants. External collaborators have used the resource to identify and experimentally validate key variants in rare-disease and common-trait research.