Microsoft's MAI-DxO beats generalist doctors on hard cases

Microsoft's MAI-DxO system, which coordinates AI agents that question patients, order tests, and debate diagnoses, was correct on 83% of complex New England Journal of Medicine cases in a Science study, versus 36% for generalist physicians working alone. The data suggests most gains come from underlying models, with Microsoft's best results using OpenAI's GPT-5 family. Microsoft AI CEO Mustafa Suleyman called it a step toward 'medical superintelligence.'

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